Can ReGeneraTing Agents Improve Functional Recovery of Transected Peripheral Nerve through a Nerve Gap Bridged with an Artery Graft?
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چکیده
منابع مشابه
P21: Local Administration of Methylprednisolone Laden Hydrogel Enhances Functional Recovery of Transected Sciatic Nerve in Rat
The repair of peripheral nerve injuries is still one of the most challenging tasks and concerns in neurosurgery. Effect of methylprednisolone-laden hydrogel loaded into a chitosan conduit on the functional recovery of peripheral nerve using a rat sciatic nerve regeneration model was assessed. A 10-mm sciatic nerve defect was bridged using a chitosan conduit (CHIT/CGP-Hydrogel) filled with CGP-h...
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Microsurgical techniques for the treatment of large peripheral nerve injuries (such as the gold standard autograft) and its main clinically approved alternative--hollow nerve guidance conduits (NGCs)--have a number of limitations that need to be addressed. NGCs, in particular, are limited to treating a relatively short nerve gap (4 cm in length) and are often associated with poor functional rec...
متن کاملeffects of pulsed electromagnetic field with predatory stress on functional and histological index of injured-sciatic nerve in rat
objective: to assess the effect of combination of pulsed electromagnetic fields (pemf) with predatory stress on transected sciatic nerve regeneration in rats. methods: in sham- operated group (sog) the nerve was manipulated and left intact. the 10-mm rat sciatic nerve gap was created in rats. in transected group (transected) nerve stumps were sutured to adjacent muscle and in vein graft group ...
متن کاملEffect of Local Administration of Brain Derived Neurotrophic Factor with Silicone Conduit on Peripheral Nerve Regeneration: a Rat Sciatic Nerve Transection Model
Objective- The objective was to assess local effect of brain derived neurotrophic factor (BDNF) on functional recovery of peripheral nerve in rat sciatic nerve transection model. Design- Experimental study. Animals- Sixty male healthy white Wistar rats Procedures- The animalswere randomized into four experimental groups of 15 animals each: In sham-operated group (SHAM), sciatic nerve was exp...
متن کاملEpisomal Induced Pluripotent Stem Cells Promote Functional Recovery of Transected Murine Peripheral Nerve
Traumatic peripheral nerve neurotmesis occurs frequently and functional recovery is often slow and impaired. Induced pluripotent stem cells (iPSCs) have shown much promise in recent years due to its regenerative properties similar to that of embryonic stem cells. However, the potential of iPSCs in promoting the functional recovery of a transected peripheral nerve is largely unknown. This study ...
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ژورنال
عنوان ژورنال: Journal of Reconstructive Microsurgery Open
سال: 2019
ISSN: 2377-0813,2377-0821
DOI: 10.1055/s-0039-1692453